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\/><\/p>\n<p>TNF\u88fd\u5264\u306e\u958b\u767a\u5f53\u521d\u306f\u540c\u7a2e\u3067\u3042\u308b\u30d2\u30c8TNF\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u88fd\u9020\u3059\u308b\u3053\u3068\u304c\u96e3\u3057\u304f\u3001\u5b8c\u5168\u30de\u30a6\u30b9\u6297\u4f53\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306a\u3069\u306e\u5f37\u3044\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8d77\u3053\u3059\u305f\u3081\u88fd\u5264\u5316\u306b\u306f\u81f3\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n\u305d\u306e\u6b20\u70b9\u3092\u88dc\u3046\u305f\u3081\u306bTNF\u306b\u53cd\u5fdc\u3059\u308b\u90e8\u5206\u3060\u3051\u3092\u30de\u30a6\u30b9\u907a\u4f1d\u5b50\u306b\u4f9d\u5b58\u3059\u308b\u30ad\u30e1\u30e9\u6297\u4f53\u3067\u3042\u308b\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u304c\u958b\u767a\u3001\u767a\u58f2\u3055\u308c\u307e\u3057\u305f\u3002\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u306e\u4f7f\u7528\u6642\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306a\u3069\u3092\u6291\u3048\u308b\u305f\u3081\u306b\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306e\u4f75\u7528\u304c\u5fc5\u9808\u3067\u3059\u3002<\/p>\n<p>\u6b21\u306b\u767a\u58f2\u3055\u308c\u305f\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u306f\u4ed6\u306e\u88fd\u5264\u3068\u7570\u306a\u308a\u3001\u30d2\u30c8\u306eTNF\u53d7\u5bb9\u4f53\u3092\u5229\u7528\u3057\u305f\u88fd\u5264\u3067\u3059\u3002\u3053\u306e\u53d7\u5bb9\u4f53\u88fd\u5264\u306b\u306f\u3001\u5b8c\u5168\u306b\u30d2\u30c8\u7531\u6765\u306e\u6210\u5206\u306e\u305f\u3081\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\u304c\u8d77\u304d\u306b\u304f\u3044\u3001\u53d7\u5bb9\u4f53\u306a\u306e\u3067TNF\u03b1\u4ee5\u5916\u306e\u4f1d\u9054\u7269\u8cea\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3044\u30462\u3064\u306e\u30e1\u30ea\u30c3\u30c8\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u5f8c\u3001\u6297\u4f53\u88fd\u9020\u6280\u8853\u306e\u5411\u4e0a\u306b\u3088\u308a\u30a2\u30c0\u30ea\u30e0\u30de\u30d6\u3001\u30b4\u30ea\u30e0\u30de\u30d6\u3068\u3044\u3063\u305f\u5b8c\u5168\u30d2\u30c8\u578b\u88fd\u5264\u304c\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u6297\u4f53\u88fd\u5264\u306b\u304a\u3044\u3066\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306e\u4f75\u7528\u304c\u5fc5\u9808\u3067\u306f\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u30bb\u30eb\u30c8\u30ea\u30ba\u30de\u30d6\u30fb\u30da\u30b4\u30eb\u3084\u30aa\u30be\u30e9\u30ea\u30ba\u30de\u30d6\u3067\u306f\u3001\u3088\u308a\u708e\u75c7\u90e8\u4f4d\u306b\u5c4a\u304d\u3084\u3059\u304f\u3059\u308b\u305f\u3081\u306bFc\u3068\u3044\u3046\u90e8\u5206\u3092\u306a\u304f\u3057\u5c0f\u578b\u5316\u3057\u305f\u88fd\u5264\u306b\u306a\u308a\u307e\u3057\u305f\u3002Fc\u304c\u306a\u304f\u306a\u308b\u3068\u85ac\u306e\u5b89\u5b9a\u6027\u304c\u5931\u308f\u308c\u4f53\u5185\u306e\u85ac\u5264\u304c\u6025\u6fc0\u306b\u5206\u89e3\u3055\u308c\u308b\u305f\u3081\u3001\u305d\u306e\u6b20\u70b9\u3092\u88dc\u3046\u305f\u3081\u306b\u3001\u524d\u8005\u306f\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306b\u3001\u5f8c\u8005\u306f\u4f53\u5185\u306e\u30a2\u30eb\u30d6\u30df\u30f3\u306b\u7d50\u5408\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u3044\u305a\u308c\u3082\u5b89\u5b9a\u6027\u3092\u78ba\u4fdd\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305fFc\u3092\u306a\u304f\u3059\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u6e1b\u5c11\u3001\u6297\u85ac\u7269\u6297\u4f53\uff08\u85ac\u5264\u306e\u52b9\u304d\u3092\u60aa\u304f\u3059\u308b\u7269\u8cea\uff09\u306e\u6e1b\u5c11\u3001\u80ce\u5150\u3084\u6bcd\u4e73\u3078\u306e\u85ac\u5264\u79fb\u884c\u3092\u5c11\u306a\u304f\u3059\u308b\u3068\u3044\u3063\u305f\u52b9\u679c\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u6295\u4e0e\u65b9\u6cd5\u3068\u3057\u3066\u306f\u3001\u5834\u6240\u3068\u6642\u9593\u306e\u78ba\u4fdd\u3092\u8981\u3059\u308b\u70b9\u6ef4\u304b\u3089\u76ae\u4e0b\u6ce8\u5c04\u3078\u79fb\u884c\u3057\u3066\u3044\u307e\u3059\u3002\u76ae\u4e0b\u6ce8\u5c04\u306e\u30e1\u30ea\u30c3\u30c8\u306f\u6295\u4e0e\u306e\u7c21\u4fbf\u3055\u3067\u3059\u304c\u3001\u30b7\u30ea\u30f3\u30b8\u3084\u30da\u30f3\u306b\u542b\u307e\u308c\u308b\u85ac\u5264\u306f\u4e00\u5b9a\u91cf\u3067\u6c7a\u307e\u3063\u3066\u304a\u308a\u3001\u4f53\u91cd\u304c\u8efd\u3044\u65b9\u304c\u52b9\u304d\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u70b9\u6ef4\u88fd\u5264\u3067\u306f\u4f53\u91cd\u306b\u5fdc\u3058\u3066\u7528\u91cf\u306e\u8abf\u6574\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u4f53\u683c\u304c\u5927\u304d\u3044\u65b9\u3067\u306f\u70b9\u6ef4\u306e\u65b9\u304c\u52b9\u304d\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3>TNF\u88fd\u5264\u306e\u9577\u6240\u3068\u77ed\u6240<\/h3>\n<p><span class=\"marker-text\">TNF\u963b\u5bb3\u85ac\u306e\u6700\u5927\u306e\u9577\u6240\u306f\u3001\u52b9\u679c\u767a\u73fe\u306e\u901f\u3055\u306b\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<p>\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u6cbb\u7642\u958b\u59cb\u5f8c3\uff0d7\u65e5\u3067\u6709\u52b9\u6027\u3092\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u3082\u3042\u308a\u307e\u3059\u3002\u5373\u52b9\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u57fa\u672c\u7684\u306b\u306f\u3069\u306e\u85ac\u5264\u3082\u5927\u304d\u306a\u5dee\u306f\u306a\u304f\u30013\u30f5\u6708\u7a0b\u3067\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u304b\u3069\u3046\u304b\u306e\u5224\u5b9a\u304c\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u95a2\u7bc0\u306e\u7834\u58ca\u3092\u9632\u6b62\u3059\u308b\u52b9\u679c\u306b\u95a2\u3057\u3066\u306f\u3001\u4ed6\u306e\u3057\u304f\u307f\u3092\u3082\u3064\u751f\u7269\u5b66\u7684\u88fd\u5264\u3067\u3082\u8a3c\u660e\u3055\u308c\u3066\u304a\u308a\u3001\u57fa\u672c\u7684\u306b\u75be\u60a3\u6d3b\u52d5\u6027\u3092\u5341\u5206\u306b\u6291\u3048\u308b\u3053\u3068\u3067\u305d\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001TNF\u963b\u5bb3\u85ac\u3067\u306f\u75be\u60a3\u6d3b\u52d5\u6027\u304c\u5341\u5206\u306b\u6291\u3048\u3089\u308c\u306a\u3044\u5834\u5408\u3067\u3082\u95a2\u7bc0\u7834\u58ca\u3092\u3042\u308b\u7a0b\u5ea6\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u95a2\u7bc0\u5c40\u6240\u306b\u304a\u3044\u3066TNF\u306b\u306f\u95a2\u7bc0\u7834\u58ca\u306b\u7279\u5225\u306a\u50cd\u304d\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305fTNF\u963b\u5bb3\u85ac\u306b\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u307f\u306a\u3089\u305a\u3001\u8840\u7ba1\u306e\u708e\u75c7\u3092\u6291\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u306e\u72ed\u5fc3\u75c7\u3084\u5fc3\u7b4b\u6897\u585e\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u554f\u984c\u70b9\u3068\u3057\u3066\u306f\u3001\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u3068\u85ac\u5264\u8cbb\u306e\u9ad8\u3055\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u611f\u67d3\u75c7\u3067\u306f\u80ba\u708e\u306a\u3069\u306e\u7d30\u83cc\u611f\u67d3\u75c7\u3001\u7d50\u6838\u3001\u30cb\u30e5\u30fc\u30e2\u30b7\u30b9\u30c1\u30b9\u80ba\u708e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u4ed6\u306e\u3057\u304f\u307f\u3092\u3082\u3064\u751f\u7269\u5b66\u7684\u88fd\u5264\u3067\u3082\u540c\u69d8\u306b\u554f\u984c\u306b\u306a\u308a\u3001\u30ea\u30b9\u30af\u3082\u307b\u3068\u3093\u3069\u540c\u3058\u3067\u3059\u3002\u5c0e\u5165\u6642\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u691c\u8a0e\u3057\u3066\u5fc5\u8981\u306a\u5bfe\u7b56\u3092\u884c\u3046\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u611f\u67d3\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u4e00\u3064\u306e\u65b9\u6cd5\u3068\u3057\u3066\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3001\u30b3\u30ed\u30ca\u3001\u80ba\u708e\u7403\u83cc\u3078\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30cb\u30e5\u30fc\u30e2\u30b7\u30b9\u30c1\u30b9\u80ba\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5834\u5408\uff08\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u4f75\u7528\u3057\u3066\u3044\u308b\u3001\u65e2\u306b\u80ba\u75be\u60a3\u304c\u3042\u308b\u300165\u6b73\u4ee5\u4e0a\u306e\u3044\u305a\u308c\u304b2\u3064\u4ee5\u4e0a\u304c\u8a72\u5f53\uff09\u306b\u306f\u6297\u83cc\u5264\u306e\u4e88\u9632\u6295\u4e0e\u3092\u884c\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u85ac\u5264\u8cbb\u6291\u5236\u306e\u4e00\u3064\u306e\u65b9\u6cd5\u3067\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3067\u6709\u52b9\u6027\u304c\u5341\u5206\u306b\u5f97\u3089\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u85ac\u5264\u306e\u6e1b\u91cf\u3084\u6295\u4e0e\u9593\u9694\u306e\u5ef6\u9577\u3092\u8003\u616e\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u85ac\u5264\u8cbb\u3092\u6291\u3048\u308b\u65b9\u6cd5\u3068\u3057\u3066\u306f\u3001\u30d0\u30a4\u30aa\u30b7\u30df\u30e9\u30fc\u3068\u3044\u308f\u308c\u308b\u5f8c\u767a\u54c1\u306e\u5c0e\u5165\u3084\u5207\u308a\u66ff\u3048\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u3001\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u3001\u30a2\u30c0\u30ea\u30e0\u30de\u30d6\u306b\u306f\u65e2\u306b\u30d0\u30a4\u30aa\u30b7\u30df\u30e9\u30fc\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u65b9\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u85ac\u4fa1\u306f\u5148\u767a\u54c1\u306e\u7d046\u5272\u3067\u3001\u901a\u5e38\u306e\u5185\u670d\u85ac\u7b49\u306e\u5f8c\u767a\u54c1\u3068\u7570\u306a\u308a\u3001\u30d0\u30a4\u30aa\u30b7\u30df\u30e9\u30fc\u3067\u306f\u767a\u58f2\u306b\u5148\u99c6\u3051\u3066\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u7fa9\u52d9\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u6bd4\u8f03\u7684\u5b89\u5fc3\u3057\u3066\u4f7f\u7528\u3057\u3066\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3><span style=\"font-size: 80%;\"><span style=\"font-size: 100%;\"><strong>\u51fa\u5178\u304a\u3088\u3073\u53c2\u8003\u8cc7\u6599<\/strong><\/span><\/span><span style=\"color: #808080; font-size: 80%;\"><br \/>\n<\/span><\/h3>\n<ul>\n<li><span style=\"font-size: 80%; color: #999999;\">Takeuchi T, et al.: Arthritis Rheum. 2022 Jun 21. doi: 10.1002\/art.42273.<\/span><\/li>\n<li><span style=\"font-size: 80%; color: #999999;\">Atsumi T, et al. Ann Rheum Dis 2016; 75: 75 83.<\/span><\/li>\n<li><span style=\"font-size: 80%; color: #999999;\">Smolen,JS, et al. Arthritis Rheum 2005; 52: 1020-1030.<\/span><\/li>\n<li><span style=\"font-size: 80%; color: #999999;\">Jacobsson LTH, et al. J Rheumtol 2005; 32: 1213.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<div class=\"pdf-link\">\n<h3>\u95a2\u9023\u30ea\u30f3\u30af<\/h3>\n<\/div>\n<div class=\"text-link\">\n<p><a href=\"https:\/\/okayama-gmc.or.jp\/shimin\/event\/rheumatism\" target=\"_blank\" rel=\"noopener\">\u5e02\u6c11\u75c5\u9662HP \u30ea\u30a6\u30de\u30c1\u6559\u5ba4\uff08\u8a18\u4e8b\u4e00\u89a7\uff09<\/a><\/p>\n<p><a href=\"https:\/\/okayama-gmc.or.jp\/shimin\/department\/arthritis-center\" target=\"_blank\" rel=\"noopener\">\u5e02\u6c11\u75c5\u9662HP \u30ea\u30a6\u30de\u30c1\u30bb\u30f3\u30bf\u30fc<\/a><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div>\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-sm-12\">\n<h3>PDF\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/h3>\n<p>\u3053\u306e\u30da\u30fc\u30b8\u3092PDF\u3067\u95b2\u89a7\u30fb\u5370\u5237\u3055\u308c\u308b\u65b9\u306f\u3053\u3061\u3089\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<div class=\"pdf-link\">\n<p><a href=\"https:\/\/okayama-gmc.or.jp\/shimin\/download_file\/4225\/0\" target=\"_blank\" rel=\"noopener\">TNF\u963b\u5bb3\u85ac\u306e\u9032\u5316<\/a><\/p>\n<\/div>\n<div class=\"text-link\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u00a0\u5e02\u6c11\u75c5\u9662\u306720\u5e74\u4ee5\u4e0a\u306b\u308f\u305f\u308a\u884c\u3063\u3066\u304d\u305f\u30ea\u30a6\u30de\u30c1\u6559\u5ba4\u3002\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u5f71\u97ff\u306b\u3088\u308a\u30012020\u5e747\u6708\u3088\u308aWeb\u7248\u30fb\u74e6\u7248\uff08&#8230;","protected":false},"author":1,"featured_media":401,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38,33],"tags":[57,119,45,81,58,82],"_links":{"self":[{"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/posts\/1233"}],"collection":[{"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/comments?post=1233"}],"version-history":[{"count":6,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/posts\/1233\/revisions"}],"predecessor-version":[{"id":1930,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/posts\/1233\/revisions\/1930"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/media\/401"}],"wp:attachment":[{"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/media?parent=1233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/categories?post=1233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/okayama-gmc.or.jp\/oth\/magazine\/wp-json\/wp\/v2\/tags?post=1233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}